Red Sox vs Astros MLB Odds, Picks and Predictions June 3

Updated: June 3, 2021

Houston, the Boston Red Sox have an Astros problem. The Astros have taken the first three games of their four-game set at Minute Maid Park, holding the Red Sox to just four runs so far in the series.

Can the Astros complete the four-game sweep when they hand the ball to Jake Odorizzi in the finale, or will the Red Sox provide value as a betting underdog and salvage a game with Martin Perez on the bump?

Check out our MLB free picks and predictions for Red Sox vs. Astros on Thursday, June 3, with first pitch scheduled for 2:10 p.m. ET.

Red Sox vs Astros game info

Location: Minute Maid Park, Houston, TX
Date: Thursday, June 3, 2021
Time: 2:10 p.m. ET
TV: SportsNet-SW, NESN

Red Sox vs Astros odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

Compare MLB odds before betting to ensure you get the best number.

The Astros opened this American League matchup as -135 home favorites and the very early money has been on the home team, moving the line to -140. The total hit the board at 9.0. Check back later for a full report from Patrick!

Check out the full line movement for this game

Red Sox vs Astros betting preview

Starting pitchers

Martin Perez (3-2, 3.55 ERA): Perez has been a pleasant surprise for this Red Sox rotation and is coming off a fantastic month of May. The lefty pitched to a 2.60 ERA with a 1.12 WHIP while limiting opponents to a .224 batting average over five starts last month.

Jake Odorizzi (0-2, 6.75 ERA): Odorizzi is making just his second start after spending five weeks on the IL. The right-hander struggled prior to the injury but was solid in his return, limiting the Padres to one run three hits over 5 1-3 innings of work. 


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

Red Sox: Zac Grotz RP (Questionable), Ryan Brasier RP (Out), Matt Carasiti RP (Out).
Astros: Michael Brantley LF (Out), Kent Emanuel RP (Out), Bryan Abreu RP (Out), Pedro Baez RP (Out), Josh James RP (Out), Austin Pruitt RP (Out). 
Find our latest MLB injury reports.

Betting trend to know

The Over is 6-0 in Astros’ last six home games against a left-handed starter. Find more MLB betting trends for Red Sox vs. Astros.

Moneyline pick

This was supposed to be a matchup of two of the best offenses in major leagues, and so far, just one has shown up. It has been a little surprising that the Astros have outscored the Red Sox 18-4 so far in this series.

Now, it will be on Jake Odorizzi to see if he can keep the Red Sox down for another game. The BoSox boast a dangerous lineup but they are definitely in a bit of a slump at the moment, scoring three runs or fewer six times in the last eight games.

But the key matchup in this game will be Martin Perez going against a red-hot Astros offense. Not only do the Astros rank first in scoring and team batting average, second in OPS, and strike out less than any team in the league, but they also smash southpaws. 

Houston ranks first in batting average and fourth in OPS when it comes to hitting off left-handers this season. And while Perez has been solid, you can make the argument he hasn’t faced a good lineup since the White Sox back on April 18, where he gave up four runs on seven hits in 3 2-3 innings.

When you consider the way the Astros hit lefties compared to the Red Sox’s current form at the dish, then you’ve got to side with the home team’s odds in this one.

PREDICTION: Astros (-140)

Covers MLB betting analysis

Over/Under pick

Wednesday’s game was the first real pitcher’s duel of this series, with the Astros squeaking out a 2-1 victory, but sportsbooks are betting two of the best offenses get back on track in this one, setting the total at 9.0 for the fourth straight game in this matchup.

Not to take anything away from Houston’s rotation, but it is a little surprising to see a Boston team that ranks fifth in scoring at 5.14 runs per game and third in batting average and OPS, struggle to score so much in this series.

While Odorizzi looked good last time out, he had allowed nine earned runs in eight innings pitched prior to getting injured and the Red Sox rank fourth in batting average and OPS against right-handed pitching. And no matter how Odorizzi pitches he will inevitably have to hand the ball to a shaky-at-times Houston bullpen that ranks 20th in ERA and 19th in WHIP. 

We’ve already laid out why we like Houston to score in this one and Boston should be able to do enough to send this one Over.

PREDICTION: Over 9 (-110)

Red Sox vs Astros betting card

  • Astros (-140)
  • Over 9 (-110)

Picks made on 6/3/2021 at 12:15 a.m. ET

MLB parlays

Did you know that if you parlayed today’s MLB Red Sox vs. Astros picks, you could win $22.73 on a $10 bet?

Use our MLB parlay calculator to create your own parlays and see their potential payouts.

Where can I bet on MLB odds?

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