Cubs vs. Cardinals, 5/21/21 MLB Betting Predictions & DFS Notes

Updated: May 20, 2021

Cubs vs. Cardinals MLB Prediction

Cubs vs. Cardinals, 5/21/21 MLB Betting Predictions & DFS Notes

One of the oldest rivalries in baseball will be renewed on Friday night at Busch Stadium in St. Louis where the Cardinals will host the Cubs at 8:15 p.m. ET. When it comes to this matchup, what’s the safest bet?

Game Snapshot

957 Chicago Cubs (-113) at 958 St. Louis Cardinals (-107); o/u 8

8:15 p.m. ET, Thursday, May 21, 2021

Busch Stadium, St. Louis, MO

Chicago Cubs DFS Spin

Kris Bryant is not in the Cubs’ starting lineup Thursday against the Nationals. It’s a routine day of rest for Bryant, who boasts a .308/.401/.615 batting line with 10 home runs and 26 RBI in 40 games this season. David Bote is at third base and hitting fifth versus Nats right-hander Joe Ross.

St. Louis Cardinals DFS Spin

Carlos Martinez (ankle) will return to the Cardinals’ starting rotation Friday against the Cubs. Martinez went on the 10-day injured list May 11 after pitching through a right ankle sprain on May 8 against the Rockies. He allowed five runs on six hits and five walks over five innings in that outing as his season ERA jumped to 4.35. The 29-yeear-old right-hander had been really sharp over his previous three starts. St. Louis will also get Miles Mikolas (shoulder) back for this weekend’s series versus Chicago.

Cubs vs. Cardinals Betting Prediction

The under is 11-5 in the last 16 meetings between these two teams in St. Louis and is 5-0-1 in the last six meetings overall. On the other side, the under is 4-1 in the Cubs’ last five road games and is 5-2-1 in their last eight games overall. On the other side, the under is 4-1-1 in the Cardinals’ last six games versus National League Central opponents and is 24-9 in their last 33 games as a home underdog.


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