Cubs vs Giants MLB Odds, Picks and Predictions June 6

Updated: June 6, 2021

Kyle Hendricks had a 2.67 ERA over five May outings, and he faces the Giants today at Oracle Park, where he has a career 2.22 ERA over four starts.

Photo By – USA TODAY Sports

The Giants are as hot as can be at the moment, winning nine of their last 11 games, so the Cubs will have their work cut out for them when these two clash at 4:05 p.m. ET.

San Francisco has taken the first three games of the weekend set but oddsmakers have the Giants as MLB betting underdogs for the finale.

Will Chicago find a way to avoid the sweep in this one? Find out in our Cubs vs. Giants picks and predictions for Sunday, June 6, with first pitch set for 4:05 p.m. ET.

Cubs vs Giants game info

Location: Oracle Park, San Francisco, CA
Date: Sunday, June 6, 2021
Time: 4:05 p.m. ET
TV: Marquee Sports Network, NBCS-BA

Cubs vs Giants odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

Compare MLB odds before betting to ensure you get the best number.

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The line opened at Chicago -110/San Francisco +102, with the total at 8.5. Early action favored thte Cubs, shifting the line to -115/-105, while the Over/Under was bet down to 8.0. Check back later for a full report from Patrick!

Check out the full line movement for this game

Cubs vs Giants betting preview

Starting pitchers

Kyle Hendricks (6-4, 4.62 ERA): After an absolutely miserable start to the season, Hendricks is beginning to look like “The Professor” again. In May, Hendricks had a 2.67 ERA over five starts and he pitched six innings of three-run ball in a win over the Padres on June 1. The righty now heads to Oracle Park, where he has a career 2.22 ERA over four starts.

Johnny Cueto (4-1, 3.45 ERA): Cueto is no longer the ace he used to be but he occasionally dials it back and turns in a stellar outing. Also, the righty’s 3.45 ERA this year would be his second-lowest mark in the last five years, so there’s no denying that he’s throwing it well right now. Cueto also happens to be better at this ballpark, as he has a 2.59 ERA at home and that number goes up to 4.50 on the road.


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

Cubs: David Bote 2B (Out).
Giants: Wilmer Flores 1B (Doubtful), Buster Posey C (Questionable), Mike Yastrzemski OF (Out), Brandon Belt 1B (Out), Tommy La Stella 2B (Out).
Find our latest MLB injury reports.

Betting trend to know

The Cubs are 12-3 in their last 15 games as favorites. Find more MLB betting trends for Cubs vs. Giants.

Moneyline pick

The Giants have won seven of their last eight games heading into this one, so it’s not going to be easy for the Cubs to take them down. However, Chicago does suspiciously come into this game as the favorite, despite the fact that San Francisco has been the better team this season and Cueto the better pitcher than Hendricks.

Having said that, baseball fans know that Hendricks is actually the better option in this game, and that makes it easier to back the sharper side this afternoon.

Hendricks hasn’t faced the Giants since 2019 but he pitched seven innings of shutout ball against them in that game. And Hendricks allowed just one earned run in 15 1-3 innings of work over two starts against San Francisco in 2018.

A lot of things have changed since then, but sometimes a starter will have some extra confidence just knowing that he has dominated the players in a certain uniform. On top of that, Hendricks has been in a groove as of late.

Chicago also has a few guys that have given Cueto trouble in their careers. Jason Heyward is 7 for 22 with two doubles, two dingers and four RBI against Cueto and Kris Bryant is 5 for 10 with a homer and two RBI.

If that’s not enough, both Joc Pederson and Anthony Rizzo have taken him deep, with Rizzo actually doing it twice. The two of them don’t have great averages against Cueto, but they have the pop to make him pay for any mistakes.

PREDICTION: Cubs (-115)

Covers MLB betting analysis

Over/Under pick

Five of Hendricks’ last seven starts have had eight or fewer runs scored and he should be able to do his part in keeping this total somewhat low.

This Giants team really doesn’t have any guys that have had Hendricks’ number, which is why he should be able to cruise through this start. And while Cueto could run into trouble with a few batters in this game, the righty isn’t likely to get completely shelled.

Overall, it just doesn’t seem all that crazy to think that this game will end with a final score of something 4-3. With a total like this, Under bettors will have a little room to breathe.

PREDICTION: Under 8.5 (-110)

Cubs vs Giants betting card

  • Cubs ML (-115)
  • Under 8.5 (-110)

Picks made on 6/06/2021 at 12:32 a.m. ET

MLB parlays

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