Dodgers vs Giants MLB Odds, Picks and Predictions May 22

Updated: May 22, 2021

After a 2-1 victory for the Los Angeles Dodgers on Friday, the team will be going for its 10th win in 11 games when it takes on the San Francisco Giants at Oracle Park in San Francisco, California on Saturday, May 22. This game starts at 7:15 p.m. ET and it should be a fun one, as these are two of the best teams in baseball this season. 

Will San Francisco even up this three-game series with a victory tonight? You’ll want to keep reading our Dodgers vs. Giants picks and predictions in order to find out. 

Dodgers vs Giants game info

Location: Oracle Park, San Francisco, CA
Date: Saturday, May 22, 2021
Time: 7:15 p.m. ET

Dodgers vs Giants odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

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As of 4:45 p.m. ET, Los Angeles is a -178 favorite at FanDuel, after opening -164 late this morning and peaking at -184. The Dodgers are getting hammered, to the tune of 86 percent of tickets and 92 percent of cash on the moneyline. The total moved from 7 (Over -120) to 7.5 (Under -118), with 65 percent of tickets/73 percent of money on the Over.

Check out the full line movement for this game

Dodgers vs Giants betting preview

Starting pitchers

Walker Buehler (2-0, 2.98 ERA): Buehler is coming off seven innings of shutout ball against the Diamondbacks on May 17, and he struck out seven batters in that game. The righty has allowed two or fewer earned runs in six of his eight starts this season, and he gives the Dodgers an unbelievable opportunity to win whenever he is out there. Also, in Buehler’s only start against the Giants last season, he gave up two earned runs in 5.2 innings and struck out six batters in a 6-2 win for Los Angeles. 

Scott Kazmir (0-0, 0.00 ERA): Kazmir hasn’t pitched in a Major League Baseball game since September 23, 2016, and that was a one-inning appearance against the Colorado Rockies. The lefty has only pitched 6.1 innings in AAA this year, too. However, he has allowed only two earned runs in that time, and the Giants clearly feel he’s capable of coming to the big leagues again. He was scratched from his start last night, and he’ll be on the mound here.


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

Dodgers: Cody Bellinger 1B (Out), A.J. Pollock OF (Out), Corey Seager SS (Out).
Giants: Wilmer Flores 1B (Out), Tommy La Stella 2B (Out).
Find our latest MLB injury reports.

Betting trend to know

The Dodgers are 9-1 in their last 10 games. Find more MLB betting trends for Dodgers vs. Giants.

Moneyline pick

It’s rather difficult to bet against the Dodgers in a situation like this. Even without some of their stars in the lineup, Los Angeles has the more dangerous overall collection of hitters, with Mookie Betts and Justin Turner still being the two best between these teams at the moment. However, with Kazmir on the mound, there’s a reasonable chance the Giants end up getting the job done here. 

The lefty hasn’t pitched in forever and it’s definitely hard to trust him out there, but it’s worth noting that Betts has struggled against left-handed pitching in his career. It’s rather surprising because he is an elite righty bat, but it’s just impossible to ignore. If Betts can’t get it going, that would put a lot of pressure on guys like Turner, Chris Taylor and Max Muncy. Turner can hit against anybody, and he’d probably be ecstatic in a matchup like this one. But the others are no sure things, making the Giants a decent value in this game. 

San Francisco also gets to go against Buehler in this game. The righty has some unbelievable stuff, and he’s a feisty competitor. However, he does occasionally lose it out on the mound. Buehler gave up three homers against the Mariners on May 11, and he walked four batters against the Diamondbacks on Monday. Los Angeles was able to win both of those games, and Buehler did end up settling in and pitching great against Seattle. But that won’t fly against a very good San Francisco team. 

The Giants just have what it takes to get to Buehler, with lefties like Mike Yastrzemski, Brandon Crawford and Brandon Belt all having the necessary pop to take Buehler yard. And Buster Posey has been unbelievable this season, so he can hit anyone right now. 

PREDICTION: Giants ML (+148)

Covers MLB betting analysis

Over/Under pick

For as good as Buehler is on the mound, three of his last four starts have gone Over the total. The reality is that the righty does occasionally run into some trouble, and the Giants have a lineup filled with lefties, who generally prefer hitting against right-handed starters. Buehler can go out there and blank any team on any given night, but this doesn’t seem like a game where he’ll completely escape trouble. San Francisco scored just one run on Friday, and it’s not easy to keep this offense down in back-to-back games. 

Also, the Dodgers will be licking their chops about getting to face a starter that was in the minors earlier in the week. Los Angeles might not be a great value to win this game, but the team is going to score a few runs. The Over seems like the right play here.  

PREDICTION: Over 7.0 (-111)

Dodgers vs Giants betting card

  • Giants (+148)
  • Over 7.0 (-111) 

Picks made on 5/22/2021 at 10:55 a.m. ET

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