Matchups, Times and Opening Lines

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Updated: May 17, 2021

After breaking New England’s 11-year AFC East title streak last season, the Buffalo Bills visit Foxborough in Week 16 in a matchup that could again help decide the division in 2021.

Photo By – USA TODAY Sports

The NFL schedule is finally released! We now know what each team’s matchups will be in this new 18-week season, including the game list for Week 16.

The NFL Week 16 matchups begin with a Thursday Night clash between the San Francisco 49ers and Tennessee Titans, features a Christmas Day tilt between the Cleveland Browns and Green Bay Packers, sees the Buffalo Bills travel to Foxborough to play the New England Patriots, and is capped off by a Monday Night Football matchup between the Miami Dolphins and New Orleans Saints.

Here is the list of all the NFL Week 16 matchups, times and opening spreads.

These are the opening NFL odds for Week 16, headlined by the Bills opening as 3.5-point road favorites over New England and Green Bay as a pick’em at home against Cleveland.

Matchup Time Spread Over/Under
49ers at Titans Thurs, 8:20 p.m. ET Titans +2 46.5
Browns at Packers Sat, 4:30 p.m. ET PK 45
Colts at Cardinals Sat, 8:15 p.m. ET Cardinals -1 50
Giants at Eagles Sun, 1 p.m. ET Eagles -1.5 46
Rams at Vikings Sun, 1 p.m. ET Vikings +2.5 48
Bills at Patriots Sun, 1 p.m. ET Patriots +3.5 47.5
Buccaneers at Patriots Sun, 1 p.m. ET Panthers +6.5 51
Jaguars at Jets Sun, 1 p.m. ET Jets -1.5 44.5
Lions at Falcons Sun, 1 p.m. ET Falcons -7.5 49
Chargers at Texans Sun, 1 p.m. ET Texans +4.5 47
Ravens at Bengals Sun, 1 p.m. ET Bengals +6.5 47.5
Bears at Seahawks Sun, 4:05 p.m. ET Seahawks -5.5 45
Steelers at Chiefs Sun, 4:25 p.m. ET Chiefs -8.5 50
Broncos at Raiders Sun, 4:25 p.m. ET Raiders -2.5 47
Washington at Cowboys Sun, 8:20 p.m. ET Cowboys -5.5 48
Dolphins at Saints Mon, 8:15 p.m. ET Saints -3.5 46.5

Odds courtesy of The SuperBook as of May 16, 2021

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