Oklahoma vs Gonzaga March Madness Odds, Picks and Predictions March 22

Updated: March 21, 2021

Rohit Ponnaiya
Clock Icon Mar 21, 2021 – 9:57 AM ET

The biggest college basketball betting line of the second round of the NCAA Tournament belongs to the Gonzaga Bulldogs, who opened as whopping 14.5-point favorites against the Oklahoma Sooners. 

The undefeated Zags have been steamrolling opponents this season and oddsmakers expect them to continue their dominant play against a Sooners squad missing one of its best players.

Here are our best free March Madness picks and predictions for Oklahoma vs. Gonzaga on Monday, March 22, with tipoff at 2:40 p.m. ET.

Oklahoma vs Gonzaga odds

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The line opened at Gonzaga -14.5, with the total at 154. Check back later for a full report from Patrick!

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Oklahoma Sooners vs Gonzaga Bulldogs betting preview


Oklahoma: De’Vion Harmon (Out).
Gonzaga: None.
Find our latest NCAA basketball injury reports.

Betting trend to know

The Sooners are 7-1 ATS in their last 8 games as an underdog. Find more NCAA betting trends for Oklahoma vs. Gonzaga.

Against the spread (ATS) pick

Gonzaga is the No. 1-ranked team in the country, with the best March Madness title odds, for good reason. The Zags are coming off a 98-55 cakewalk over Norfolk State in the first round where they easily covered the 33-point spread placed in front of them. They put all their talents on full display in that contest: Ball movement, lights-out shooting, length, depth, and underrated defensive play.

This is a team that ranks first in the country in adjusted offensive efficiency, according to KenPom, while ranking seventh in adjusted defensive efficiency. That said, laying 14.5 points is no small order, especially when you consider that their spread is nearly twice as high as the second-biggest line of the second round of the NCAA Tournament. 

Oklahoma is having an up-and-down season but was ranked among the Top-10 schools in the country as little as four weeks ago. However, the Sooners closed out their regular season with four consecutive losses and are now just 1-7 ATS in their last eight contests. Oklahoma is fresh off a gritty 72-68 win over Missouri after finding out that second-leading scorer De’Vion Harmon would miss at least the first two rounds of the tourney after testing positive for COVID-19. 

The Sooners don’t really stand out in any one area of the game but they are solid on both ends of the floor. While they have suffered their share of losses in recent months they have been competitive in virtually all of them. They lost a pair of close contests to rival Oklahoma State, fell to Kansas by seven points, Texas by four, Texas Tech by five, and Kansas State by five (probably the worst loss on their resume).

Gonzaga has been breezing by foes but besides a 23-point rout of Virginia on boxing day, they’re typically not beating their best opponents by 15+ points. Their last two wins against BYU came by 10 and 11 points, while victories against West Virginia, Iowa, and Kansas were all between 5-12 points.

The Sooners don’t shoot themselves in the foot, rarely turning the ball over and committing among the fewest fouls in the country. It might not feel close, but they should do enough to cover the spread. 

PREDICTION: Oklahoma +14.5 (-110)

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Over/Under Pick

Even without Harmon, the Sooners should be solid on offense with guard Elijah Harkless stepping up with 16 points against Mizzou. They’re not a great outside shooting team and don’t rack up points in transition, but they are efficient in the half court. They also boast an All-Big 12 first team member in guard Austin Reaves, who leads the team with 17.9 points and 4.8 assists per game. 

While the Sooners are pretty good at putting up points, the Zags are off the charts. Led by Corey Kispert, Drew Timme and Jalen Suggs, Gonzaga shoots a scorching 55.1 percent from the field while averaging 92.9 ppg—both numbers good for best in the country. The Zags also play at a very fast pace, ranking fourth in the nation in adjusted tempo.

Gonzaga tends to play higher-scoring games against quality foes, going 23-9 O/U in its last 32 games against teams with a winning percentage above .600. The Zags also have a recent history of cashing Overs at this time of the year, going above the total in 13 of their previous 19 NCAA Tournament games. Back the Over again.   

PREDICTION: Over 154 (-110)

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First half pick

We mentioned that the Sooners have stayed competitive in almost all of their losses but that hasn’t always been true in the first half of those contests.

They trailed Texas by ten points at halftime and had ugly first-half deficits against both Kansas and Texas Tech, where they scored just 15 and 18 points, respectively. They were also outscored 42-25 by Baylor in the first 20 minutes when the two sides met up at the beginning of January.

Gonzaga has been all about fast starts, posting an average first-half margin of plus-14.2 ppg, easily the best mark in the country. Take the Zags on the first-half spread. 

PREDICTION: First half Gonzaga -8 (-110)

Oklahoma vs Gonzaga betting card

  • Oklahoma +14.5 (-110)
  • Over 154 (-110)
  • First half Gonzaga -8 (-110)

March Madness parlays

Did you know that if you parlayed today’s March Madness Oklahoma vs. Gonzaga picks, you could win $59.58 on a $10 bet?

Use our March Madness parlay calculator to create your own parlays and see their potential payouts.

Where can I bet on March Madness odds?

March Madness is one of the most popular times of the year for sports bettors, which of course makes it one of the busiest times of the year for online sportsbooks. Every betting site will offer March Madness odds but the top sites are safe and secure, offer a wide range of banking options, and give you a ton of markets for each game. Check out the best March Madness betting sites in your region.

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