Oregon vs Iowa March Madness Odds, Picks and Predictions March 22

Updated: March 21, 2021

Clock Icon Mar 21, 2021 – 2:13 AM ET

Sometimes you can say that a team wasn’t really tested in the first round of the NCAA Tournament but that would literally be true about the No. 7 seed Oregon Ducks, who advanced after their scheduled opponent VCU was forced to withdraw.

Now Oregon will take on the No. 2 seed Iowa Hawkeyes in the second round of the West Region and college basketball betting lines have the Ducks installed as 4-point underdogs. 

Here are our best free March Madness picks and predictions for Oregon vs. Iowa on Monday, March 22.

Oregon vs Iowa odds

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The line opened at Iowa -4, with the total at 146.5. Check back later for a full report from Patrick!

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Oregon Ducks vs Iowa Hawkeyes betting preview


Oregon: N’Faly Dante C (Out).
Iowa: Jack Nunge F (Out).
Find our latest NCAA basketball injury reports.

Betting trend to know

The Over is 6-0 in the Hawkeyes last six NCAA Tournament games. Find more NCAA betting trends for Oregon vs. Iowa.

Against the spread (ATS) pick

The Ducks were gifted a bye into the second round but they might actually wish they had a bit of a tune-up since the last time they saw the court, 10 days ago, they lost 75-64 to Oregon State in the Pac-12 semifinals. Prior to that defeat, Oregon had gone 5-0 SU and ATS in its previous five games.

The Ducks are a strong offensive team that ranks 14th in the country in adjusted offensive efficiency according to KenPom. All five of their starters average double-digits in scoring, led by Eugene Omoruyi and Chris Duarte who are tied for the team lead with 16.7 points per game.

Iowa is coming off an 86-74 win over Grand Canyon which never felt quite as close as that final scoreline might suggest. While beating up on a WAC program like Grand Canyon might seem like child’s play, it’s still impressive that the Hawkeyes shot a sizzling 54 percent from the floor against an Antelopes team that, prior to that contest, had the second-best opponent field goal percentage in the country.

Iowa is currently sixth on the March Madness odds board at +1,600 to win the National Championship. The Hawkeyes are 9-2 SU in their last 11 games and have the second-best adjusted offensive efficiency in the country. They are an experienced and deep squad that rarely makes mistakes, committing the fewest turnovers per possession in the country. Their top player is All-American center Luka Garza, who racks up 23.7 points and 8.8 rebounds per game.  

Garza could be the deciding factor in this matchup because as many offensive weapons as the Ducks have, they severely lack size. Omoruyi is the Ducks biggest starter at just 6-foot-6, while Oregon’s tallest rotation player is 6-foot-8, 205-pound backup forward Chandler Lawson.

The Ducks rank just 179th in the country in opponent two-point field goal percentage (50 percent) and were outrebounded 37-23 in their previous game. Garza shoots 58 percent from inside the arc and should be able to exploit the Ducks weakness inside. Back the Hawkeyes on the spread. 

PREDICTION: Iowa -4 (-110)

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Over/Under Pick

While the Ducks won’t be able to defend against the Hawkeyes in the paint, Iowa won’t be able to match up with Oregon’s multiple threats on the perimeter.

The Hawkeyes don’t have the most athletic defenders and allow opponents to shoot 34.9 percent from long range, which ranks outside the Top 250. That’s bad news against a Ducks team that is 27th in the country in 3-point shooting by hitting 38 percent of their shots from beyond the arc.

That said, the Hawkeyes live up to their nickname with their own sharpshooting and rank third in the country in 3-point percentage by converting at a 39.6 percent clip. There’s a reason Iowa averages 85 ppg—and it’s not just Garza.

With the Over 6-0 in Iowa’s last six NCAA Tournament games, and the Ducks 8-1-2 O/U in their previous 11 contests at a neutral site, expect a shootout on Monday.

PREDICTION: Over 146.5 (-110)

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First Half Pick

Iowa often gets off to fast starts, ranking fourth in the country in first-half scoring with 40.9 points per game while ranking 12th in average first-half margin at plus-7.2 ppg. 

The Ducks are much less impressive at the beginning of games, posting an average first-half margin of plus-1.5 ppg. They trailed by ten points at halftime in their last game against Oregon State and could come out a bit flat against the Hawkeyes since they didn’t get to settle in with a first-round matchup on Saturday. Take Iowa on the first-half spread. 

PREDICTION: First Half Iowa -2 (-110)

Oregon vs Iowa betting card

  • Iowa -4 (-110)
  • Over 146.5 (-110)
  • First Half Iowa -2 (-110)

March Madness parlays

Did you know that if you parlayed today’s March Madness Oregon vs. Iowa picks, you could win $59.58 on a $10 bet?

Use our March Madness parlay calculator to create your own parlays and see their potential payouts.

Where can I bet on March Madness odds?

March Madness is one of the most popular times of the year for sports bettors, which of course makes it one of the busiest times of the year for online sportsbooks. Every betting site will offer March Madness odds but the top sites are safe and secure, offer a wide range of banking options, and give you a ton of markets for each game. Check out the best March Madness betting sites in your region.

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